(19)

(11)

EP 1 648 437 A2

(12)

(88) Date of publication A3: 10.11.2005 (43) Date of publication: 26.04.2006 Bulletin 2006/17 (21) Application number: 04777536.6 (22) Date of filing: 01.07.2004

(51) International Patent Classification (IPC):  A61K 31/175(1985.01) A61P 43/00(2000.01) A61K 31/00(1985.01) A61P 25/28(2000.01) A61P 35/00(2000.01) (86) International application number: PCT/US2004/021465 (87) International publication number: WO 2005/002672 (13.01.2005 Gazette 2005/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 01.07.2003 US 483949 P 23.12.2003 US 532158 P (71) Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE Cambridge, MA 02138 (US) Biomol International L.P. Plymouth Meeting, PA 19462-1202 (US)	(72) Inventors: SINCLAIR, David, A. West Roxbury, MA 02132 (US) HOWITZ, Konrad, T. Allentown, PA18104 (US) ZIPKIN, Robert, E. Wynnewood, PA 19096 (US) BITTERMAN, Kevin, J. Boston, MA 02115 (US) (74) Representative: Vossius & Partner  Siebertstrasse 4 81675 München 81675 München (DE)