(19)

(11)

EP 1 648 456 A1

(12)

(43) Date of publication: 26.04.2006 Bulletin 2006/17 (21) Application number: 04742001.3 (22) Date of filing: 19.07.2004

(51) International Patent Classification (IPC):  A61K 31/439(2000.01) A61K 31/495(1985.01) A61P 9/06(2000.01) A61K 31/4995(2000.01) (86) International application number: PCT/EP2004/051532 (87) International publication number: WO 2005/011690 (10.02.2005 Gazette 2005/06)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 21.07.2003 EP 03102243 (71) Applicant: Solvay Pharmaceuticals GmbH 30173 Hannover (DE)	(72) Inventors: CAUTREELS, Werner NL-1381 XA Weesp (NL) STEINBORN, Claus 30938 Burgwedel (DE) STRAUB, Matthias 30890 Barsinghausen (DE) BECKMANN, Katrin 30173 Hannover (DE) JANSEN, Johannes Wilhelmus Catherine Maria NL-4105 LE Culemborg (NL) (74) Representative: Gosmann, Martin et al c/o Solvay Pharmaceuticals GmbH, PH-ZP (IPSI), Hans Böckler Allee 20 30173 Hannover 30173 Hannover (DE)