(19)
(11) EP 1 648 509 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
24.10.2012 Bulletin 2012/43

(45) Mention of the grant of the patent:
12.09.2012 Bulletin 2012/37

(21) Application number: 04778409.5

(22) Date of filing: 15.07.2004
(51) International Patent Classification (IPC): 
A61K 39/395(2006.01)
G01N 33/53(2006.01)
C12N 5/10(2006.01)
A61P 35/00(2006.01)
 C07K 16/22(2006.01)
C12N 15/68(2006.01)
A61P 25/00(2006.01)
(86) International application number:
PCT/US2004/022876
(87) International publication number:
WO 2005/019266 (03.03.2005 Gazette 2005/09)

(54)

HUMAN ANTI-NGF NEUTRALIZING ANTIBODIES AS SELECTIVE NGF PATHWAY INHIBITORS

HUMANE ANTI-NGF NEUTRALISIERENDE ANTIKÖRPER ALS SELEKTIVE NGF-HEMMER

ANTICORPS NEUTRALISANTS ANTI-NGF HUMAINS UTILISES COMME INHIBITEURS SELECTIFS DE LA VOIE DE NGF

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
Designated Extension States:
AL HR LT LV MK

(30) Priority: 15.07.2003 US 487431 P

(43) Date of publication of application:
26.04.2006 Bulletin 2006/17

(60) Divisional application:
10011652.4 / 2364728

(73) Proprietors:
  • Amgen Inc.
    Thousand Oaks, CA 91320-1799 (US)
  • Medarex, Inc.
    Princeton, NJ 08543 (US)

(72) Inventors:
  • WILD, Kenneth, D., Jr.
    Simi Valley, CA 93065 (US)
  • TREANOR, James, J., S.
    Sherman Oaks, CA 91423 (US)
  • HUANG, Haichun
    Fremont, CA 94539 (US)
  • INOUE, Heather
    Oak Park, CA 91377 (US)
  • ZHANG, Tie, J.
    Thousand Oaks, CA 91320 (US)
  • MARTIN, Frank
    Newbury Park, CA 91320 (US)

(74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser 
Leopoldstrasse 4
80802 München
80802 München (DE)


(56) References cited: : 
WO-A-01/78698
US-A1- 2001 046 959
 WO-A-02/096458
   
  • HOLT L J ET AL: "Domain antibodies: proteins for therapy" TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 21, no. 11, November 2003 (2003-11), pages 484-490, XP004467495 ISSN: 0167-7799
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).