(19)

(11)

EP 1 648 927 A1

(12)

(43) Date of publication: 26.04.2006 Bulletin 2006/17 (21) Application number: 04778719.7 (22) Date of filing: 20.07.2004

(51) International Patent Classification (IPC):  C07K 14/165(1995.01) A61K 39/42(1985.01) A61K 39/215(1985.01) A61K 38/16(1995.01) (86) International application number: PCT/US2004/023345 (87) International publication number: WO 2005/010034 (03.02.2005 Gazette 2005/05)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 21.07.2003 US 489166 P 25.11.2003 US 524642 P (71) Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Rockville, MD 20852-3804 (US)	(72) Inventors: DIMITROV, Dimiter S. Rockville, Maryland 20852 (US) XIAO, Xiaodong Frederick, Maryland 21702 (US) (74) Representative: Leifert & Steffan  Patentanwälte, Burgplatz 21-22 40213 Düsseldorf 40213 Düsseldorf (DE)