(19)

(11)

EP 1 648 999 A2

(12)

(88) Date of publication A3: 02.06.2005 (43) Date of publication: 26.04.2006 Bulletin 2006/17 (21) Application number: 04777155.5 (22) Date of filing: 25.06.2004

(51) International Patent Classification (IPC):  C12N 1/00(1980.01) (86) International application number: PCT/US2004/020594 (87) International publication number: WO 2005/012480 (10.02.2005 Gazette 2005/06)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 25.06.2003 US 482820 P 20.08.2003 US 496467 P (71) Applicant: MacroPore Biosurgery, Inc. San Diego, California 92121 (US)	(72) Inventors: HEDRICK, Marc, H. Encino, CA 91436 (US) FRASER, John, K. Los Angeles, CA 90064 (US) SCHULZKI, Michael, J. San Diego, CA 92121 (US) BYRNES, Bobby San Diego, CA 92121 (US) CARISON, Grace San Diego, CA 92121 (US) (74) Representative: Baker, Colin John  Eric Potter Clarkson LLP Park View House 58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)