(19)

(11)

EP 1 649 054 A1

(12)

(43) Date of publication: 26.04.2006 Bulletin 2006/17 (21) Application number: 04747831.8 (22) Date of filing: 15.07.2004

(51) International Patent Classification (IPC):  C12Q 1/68(1980.01) G01N 33/50(1980.01) A61K 31/7088(2000.01) C12N 15/11(1990.01) A61K 39/395(1985.01) A61P 35/00(2000.01) (86) International application number: PCT/JP2004/010442 (87) International publication number: WO 2005/007889 (27.01.2005 Gazette 2005/04)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 21.07.2003 US 488924 P (71) Applicant: Oncotherapy Science, Inc. Kawasaki-shi, Kanagawa 213-0012 (JP)	(72) Inventors: NAKAMURA, Yusuke Yokohama-shi, Kanagawa 2250011 (JP) FURUKAWA, Yoichi Kawasaki-shi, Kanagawa 2160033 (JP) (74) Representative: Vossius & Partner  Siebertstrasse 4 81675 München 81675 München (DE)