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(11)

EP 1 651 210 A1

(12)

(43) Date of publication: 03.05.2006 Bulletin 2006/18 (21) Application number: 04744112.6 (22) Date of filing: 19.07.2004

(51) International Patent Classification (IPC):  A61K 31/415(1985.01) A61K 31/545(1985.01) A61K 9/00(1968.09) A61P 15/14(2000.01) A61K 31/167(2000.01) A61K 31/546(2000.01) A61P 27/16(2000.01) (86) International application number: PCT/IB2004/002461 (87) International publication number: WO 2005/009436 (03.02.2005 Gazette 2005/05)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 31.07.2003 US 492121 P (71) Applicant: Pharmacia & Upjohn Company LLC Kalamazoo, MI 49001 (US)

(72) Inventors: BRITTEN, N. J.; c/o Pfizer Global R. & D. Kalamazoo, MI 49001 (US) WALDRON, Niki Ann; c/o Pfizer Global R. & D. Kalamazoo, MI 49001 (US) WATTS, Jeffrey Lynn; c/o Pfizer Global R. & D. Kalamazoo, MI 49001 (US) HALLBERG, John Walter; c/o Pfizer Global R. & D. Kalamazoo, MI 49001 (US) BURNS, John William Antigo, WI 54409 (US) (74) Representative: Rutt, Jason Edward  Pfizer Limited European Patents Department, Ramsgate Road Sandwich, Kent CT13 9NJ Sandwich, Kent CT13 9NJ (GB)