(19)

(11)

EP 1 651 222 A1

(12)

(43) Date of publication: 03.05.2006 Bulletin 2006/18 (21) Application number: 04741128.5 (22) Date of filing: 17.07.2004

(51) International Patent Classification (IPC):  A61K 31/46(1985.01) A61K 45/06(1985.01) A61K 31/44(1985.01) A61P 11/00(2000.01) A61K 31/19(1985.01) (86) International application number: PCT/EP2004/008024 (87) International publication number: WO 2005/013993 (17.02.2005 Gazette 2005/07)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 29.07.2003 EP 03017164 (71) Applicants: Boehringer Ingelheim International GmbH 55216 Ingelheim (DE) AT BE BG CH CY CZ DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR  Boehringer Ingelheim Pharma GmbH & Co. KG 55216 Ingelheim (DE) DE	(72) Inventors: MEADE, Christopher, John, Montague 88437 MASELHEIM (DE) PAIRET, Michel 88400 BIBERACH (DE) PIEPER, Michael, P. 88400 BIBERACH (DE) (74) Representative: Hammann, Heinz et al Boehringer Ingelheim Pharma GmbH & Co. KG Binger Strasse 173 55216 Ingelheim am Rhein 55216 Ingelheim am Rhein (DE)