(19)

(11)

EP 1 651 251 A2

(12)

(88) Date of publication A3: 14.04.2005 (43) Date of publication: 03.05.2006 Bulletin 2006/18 (21) Application number: 04779234.6 (22) Date of filing: 27.07.2004

(51) International Patent Classification (IPC):  A61K 38/28(1995.01) A61K 31/44(1985.01) A61K 31/41(1985.01) (86) International application number: PCT/US2004/024073 (87) International publication number: WO 2005/012485 (10.02.2005 Gazette 2005/06)

(84) Designated Contracting States: DE ES FR GB IT (30) Priority: 31.07.2003 US 491730 P (71) Applicant: Bayer Pharmaceuticals Corporation West Haven, CT 06516 (US)	(72) Inventor: SWEET, Laurel Branford, CT 06405 (US) (74) Representative: Burkert, Frank  Bayer HealthCare AG LP-PL, Q18 51368 Leverkusen 51368 Leverkusen (DE)