(19)

(11)

EP 1 653 939 A2

(12)

(88) Date of publication A3: 15.09.2005 (43) Date of publication: 10.05.2006 Bulletin 2006/19 (21) Application number: 04780406.7 (22) Date of filing: 06.08.2004

(51) International Patent Classification (IPC):  A61K 31/192(2000.01) A61K 31/341(2000.01) A61K 31/381(2000.01) A61K 31/44(1985.01) A61P 3/00(2000.01) A61P 35/00(2000.01) A61K 31/196(2000.01) A61K 31/343(2000.01) A61K 31/385(1985.01) A61K 31/505(1985.01) A61P 25/00(2000.01) (86) International application number: PCT/US2004/025564 (87) International publication number: WO 2005/013949 (17.02.2005 Gazette 2005/07)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 07.08.2003 US 493138 P 31.12.2003 US 533734 P (71) Applicant: ALLERGAN, INC. Irvine, California 92612 (US)	(72) Inventors: JIANG, Guang, Liang Lake Forest, CA 92610 (US) YUAN, Yang-Dar Irvine, CA 92603 (US) CHANDRARATNA, Roshantha, A. Laguna Hills, CA 92653 (US) (74) Representative: Stevens, Ian Edward  Eric Potter Clarkson LLP Park View House 58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)