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EP 1 653 966 A1

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(43) Date of publication: 10.05.2006 Bulletin 2006/19 (21) Application number: 04743948.4 (22) Date of filing: 12.07.2004

(51) International Patent Classification (IPC):  A61K 31/519(2000.01) A61K 31/496(2000.01) A61P 15/00(2000.01) A61K 31/635(1985.01) A61K 31/00(1985.01) (86) International application number: PCT/IB2004/002286 (87) International publication number: WO 2005/007166 (27.01.2005 Gazette 2005/04)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 16.07.2003 GB 0316673 01.08.2003 GB 0318095 11.09.2003 GB 0321308 (71) Applicants: Pfizer Limited Sandwich, Kent CT13 9NJ (GB) GB  PFIZER INC. New York, N.Y. 10017 (US) AT BE BG CH CY CZ DE DK EE ES FI FR GR HU IE IT LU MC NL PL PT RO SE SI SK TR

(72) Inventors: NAYLOR, Alasdair, Mark, Pfizer Global Res. & Dev. Sandwich, Kent CT13 9NJ (GB) VAN DER GRAAF, Pieter, H. Pfizer Global Res & Dev. Sandwich, Kent CT13 9NJ (GB) WAYMAN, Christopher, P. Pfizer Global Res. & Dev. Sandwich, Kent CT13 9NR (GB) (74) Representative: Nevant, Marc et al Pfizer European Patent Department 23-25, avenue du Docteur Lannelongue 75668 Paris Cedex 14 75668 Paris Cedex 14 (FR)