(19)

(11)

EP 1 654 031 A1

(12)

(43) Date of publication: 10.05.2006 Bulletin 2006/19 (21) Application number: 04756982.7 (22) Date of filing: 12.07.2004

(51) International Patent Classification (IPC):  A61N 1/18(1968.09) (86) International application number: PCT/US2004/022587 (87) International publication number: WO 2005/007237 (27.01.2005 Gazette 2005/04)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 11.07.2003 US 486573 P (71) Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA Los Angeles, CA 90007-4344 (US)	(72) Inventors: LOEB, Gerald, E. South Pasadena, CA 91030 (US) KAPLAN, Hilton, M. Beverly Hills, CA 90210 (US) (74) Representative: Hill, Justin John et al McDermott Will & Emery UK LLP 7 Bishopsgate London EC2N 3AR London EC2N 3AR (GB)