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(11)

EP 1 654 236 A1

(12)

(43) Date of publication: 10.05.2006 Bulletin 2006/19 (21) Application number: 04756894.4 (22) Date of filing: 12.07.2004

(51) International Patent Classification (IPC):  C07D 233/54(1985.01) C07C 211/19(1990.01) A61K 31/4164(2000.01) C07D 249/04(1985.01) A61P 35/00(2000.01) A61K 31/4192(2000.01) (86) International application number: PCT/US2004/022282 (87) International publication number: WO 2005/007631 (27.01.2005 Gazette 2005/04)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV (30) Priority: 10.07.2003 US 486382 P (71) Applicant: OSI Pharmaceuticals, Inc. Melville, New York 11747 (US)

(72) Inventors: SMITH, Vanessa Oxford OX4 6LT (GB) NIGRO, Anthony Farmingdale, NY 11735 (US) MULVIHILL, Mark Farmingdale, NY 11735 (US) CESARIO, Cara Farmingdale, NY 11735 (US) BECK, Patricia, Anne Farmingdale, NY 11735 (US) CASTELANO, Arlindo, Lucas Farmingdale, NY 11735 (US) (74) Representative: Blakey, Alison Jane  Prosidion Limited Windrush Court Watlington Road Oxford OX4 6LT Oxford OX4 6LT (GB)