(19)
(11) EP 1 654 241 A1

(12)

(43) Date of publication:
10.05.2006 Bulletin 2006/19

(21) Application number: 04740596.4

(22) Date of filing: 02.07.2004
(51) International Patent Classification (IPC): 
C07D 273/02(1985.01)
A61P 25/00(2000.01)
 C07D 291/08(1985.01)
A61K 31/33(1985.01)
(86) International application number:
PCT/EP2004/007247
(87) International publication number:
WO 2005/003106 (13.01.2005 Gazette 2005/02)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

(30) Priority: 03.07.2003 GB 0315654

(71) Applicants:
  • Novartis AG
    4056 Basel (CH)

    BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR 
  • Novartis Pharma GmbH
    1230 Vienna (AT)

    AT 

(72) Inventors:
  • BETSCHART, Claudia
    CH-4054 Basel (CH)
  • TINTELNOT-BLOMLEY, Marina
    79689 Maulburg (DE)

(74) Representative: Leon, Susanna Iris 
Novartis AG Corporate Intellectual Property P.O. Box
4002 Basel
4002 Basel (CH)

   


(54) MACROCYCLIC COMPOUNDS HAVING ASPARTIC PROTEASE INHIBITING ACTIVITY AND PHARMACEUTICAL USES THEREOF