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EP 1 658 264 A2

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(88) Date of publication A3: 13.10.2005 (43) Date of publication: 24.05.2006 Bulletin 2006/21 (21) Application number: 04743998.9 (22) Date of filing: 21.06.2004

(51) International Patent Classification (IPC):  C07C 309/14(1990.01) (86) International application number: PCT/IB2004/002337 (87) International publication number: WO 2004/113277 (29.12.2004 Gazette 2004/53)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 23.06.2003 US 480906 P 17.10.2003 US 512047 P 18.06.2004 US 871514 18.06.2004 US 871365 (71) Applicants: Neurochem (International) Limited 1015 Lausanne (Ecublens) (CH) QUEEN'S UNIVERSITY AT KINGSTON Kingston, Ontario K7L 3N6 (CA)

(72) Inventors: KONG, Xianqi Dollard-des-Ormeaux, Quebec H9B 3J7 (CA) GERVAIS, Francine Ile Bizard, Quebec H9C 2X5 (CA) SZAREK, Walter A. Kingston, Ontario K7L 2Y6 (CA) (74) Representative: HOFFMANN EITLE  Patent- und Rechtsanwälte Arabellastrasse 4 81925 München 81925 München (DE)