(19)

(11)

EP 1 660 017 A2

(12)

(43) Date of publication: 31.05.2006 Bulletin 2006/22 (21) Application number: 04816791.0 (22) Date of filing: 29.07.2004

(51) International Patent Classification (IPC):  A61K 6/00(1980.01) (86) International application number: PCT/US2004/024901 (87) International publication number: WO 2005/046575 (26.05.2005 Gazette 2005/21)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 29.07.2003 US 491331 P (71) Applicant: Signature R&D Holdings, LLC Allen, TX 75002 (US)	(72) Inventor: CHANDRAN, V. Ravi Richardson, TX 75080 (US) (74) Representative: HOFFMANN EITLE  Patent- und Rechtsanwälte Arabellastrasse 4 81925 München 81925 München (DE)