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<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESI....FIRO..CY..TRBGCZEEHUPLSK....................................</B001EP><B005EP>J</B005EP><B007EP>DIM360 Ver 2.15 (14 Jul 2008) -  2999001/0</B007EP></eptags></B000><B100><B110>1661911</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20130213</date></B140><B150><B151>W1</B151><B153>73</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>04772501.5</B210><B220><date>20040831</date></B220><B240><B241><date>20060302</date></B241><B242><date>20100715</date></B242></B240><B250>ja</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>2003314187</B310><B320><date>20030905</date></B320><B330><ctry>JP</ctry></B330></B300><B400><B405><date>20130213</date><bnum>201307</bnum></B405><B430><date>20060531</date><bnum>200622</bnum></B430><B450><date>20121107</date><bnum>201245</bnum></B450><B452EP><date>20120521</date></B452EP><B480><date>20130213</date><bnum>201307</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>C07K  14/31        20060101AFI20050322BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>A61K  39/085       20060101ALI20050322BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>A61P  37/08        20060101ALI20050322BHEP        </text></classification-ipcr><classification-ipcr sequence="4"><text>C12N  15/31        20060101ALI20050322BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>PROTEASE-RESISTENTE SEB-VARIANTE UND DIESE ENTHALTENDER IMPFSTOFF</B542><B541>en</B541><B542>PROTEASE-RESISTANT MODIFIED SEB AND VACCINE CONTAINING THE SAME</B542><B541>fr</B541><B542>VARIANTE DE L'ENTEROTOXINE B DU STAPHYLOCOQUE DORE RESISTANT AUX PROTEASES ET VACCIN EN CONTENANT</B542></B540><B560><B561><text>EP-A- 1 055 429</text></B561><B561><text>WO-A-93/14634</text></B561><B561><text>WO-A1-99/40935</text></B561><B561><text>JP-A- 8 500 328</text></B561><B562><text>PAPAGEORGIOU A C ET AL: "Crystal structure of the superantigen enterotoxin C2 from Staphylococcus aureus reveals a zinc-binding site" STRUCTURE, CURRENT BIOLOGY LTD., PHILADELPHIA, PA, US, vol. 3, no. 8, 1 August 1995 (1995-08-01), pages 769-779, XP004587900 ISSN: 0969-2126</text></B562><B562><text>WOODY MA. ET AL: 'STAPHYLOCOCCAL ENTEROTOXIN B MUTANTS (N23K AND F44S):BIOLOGICAL EFFECTS AND VACCINE POTENTIAL IN A MOUSE MODEL' VACCINE vol. 15, no. 2, 1997, pages 133 - 139, XP004054362</text></B562><B562><text>BOLES JW.ET AL.: 'GENERATION OF PROTECTIVE IMMUNITY BY INACTIVATED RECOMBINANT STAPHYLOCOCCAL ENTEROTOXIN B VACCINE IN NINHUMAN PRIMATES AND IDENTIFICATION OF CORRELATES OF IMMUNITY' CLIN.IMMUNOL. vol. 108, no. 1, July 2003, pages 51 - 59, XP002903427</text></B562><B562><text>MAGAGNOLI C, ET AL.: 'MUTATIONS IN THE A SUBUNIT AFFECT YIELD, STABILITY, AND PROTEASE OF NONTOXIC DERIVATIVES OF HEAT-LABILE ENTEROTOXIN' INFECT.IMMUN, vol. 64, no. 12, 1996, pages 5434 - 5438, XP002970709</text></B562><B562><text>SPERO L. ET AL: 'EFFECT OF SINGLE PEPTIDE BOND SCISSION BY TRYPSIN ON THE STRUCTURE AND ACTIVITY OF STAPHYLOCCAL ENTEROTOXIN B,' J.BIOL.CHEM. vol. 248, no. 21, 1973, pages 7289 - 7294, XP002903428</text></B562><B562><text>ROGGIANI M. ET AL: 'ANALYSIS OF TOXICITY OF STREPTOCOCCAL PYROGENIC EXOTOXIN A MUTANTS' INFECT.IMMUN. vol. 65, no. 7, 1997, pages 2868 - 2875, XP002067015</text></B562><B562><text>KLINE JB ET AL: 'ANALYSIS OF THE SUPERANTIGENIC ACTIVITY OF MUTANT AND ALLELIC FORMS OF STREPTOCOCCAL PYROGENIC EXOTOXIN A.' INFECT IMMUN. vol. 65, no. 3, 1996, pages 861 - 869, XP002066999</text></B562><B562><text>DERESIEWICZ RL ET AL: 'MUTATIONS AFFECTING THE ACTIVITY OF TOXIC SHOCK SYNDROME TOXIN-1' BIOCHEMISTRY vol. 33, no. 43, 1994, pages 12844 - 12851, XP002903429</text></B562><B562><text>LEDER L.ET AL: 'A MUTATIONAL ANALYSIS OF THE BINDING OF STAPHYLOCOCCAL ENTEROTOXINS B AND C3 TO THE T CELL RECEPTOR BETA CHAIN ANDMAJOR HISTOCOMPATIBILITY COMPLEX CLASS II' J.EXP.MED. vol. 187, no. 6, 1998, pages 823 - 833, XP002903430</text></B562><B565EP><date>20080820</date></B565EP></B560></B500><B700><B720><B721><snm>NAKASHIMA, Toshihiro
c/o JURIDICAL FOUNDATION THE</snm><adr><str>CHEMO-SERO-THER. RES. INS.
1314-1, Kyokushi-Kawabe</str><city>Kikuchi-shi
Kumamoto-ken 869-1298</city><ctry>JP</ctry></adr></B721><B721><snm>SASAKI, Takumi
c/o JURIDICAL FOUNDATION THE</snm><adr><str>CHEMO-SERO-THER. RES. INS.
1314-1, Kyokushi-Kawabe</str><city>Kikuchi-shi
Kumamoto-ken 869-1298</city><ctry>JP</ctry></adr></B721><B721><snm>NISHIHARA, Tsukasa
c/o JURIDICAL FOUNDATION THE</snm><adr><str>CHEMO-SERO-THER. RES. INS.
1314-1, Kyokushi-Kawabe</str><city>Kikuchi-shi
Kumamoto-ken 869-1298</city><ctry>JP</ctry></adr></B721><B721><snm>TAKEMOTO, Sumiyo
c/o JURIDICAL FOUNDATION THE</snm><adr><str>CHEMO-SERO-THER. RES. INS.
6-1, Okubo 1-chome</str><city>Kumamoto-shi,
Kumamoto-ken 860-8568</city><ctry>JP</ctry></adr></B721><B721><snm>SAKATA, Atsuko</snm><adr><str>1604-1, Yomogimachi,
Kumamoto-shi</str><city>Kumamoto-ken 861-5515</city><ctry>JP</ctry></adr></B721><B721><snm>OHKUCHI, Masao</snm><adr><str>3-9-5, Nakaarai,
Tokorozawa-shi</str><city>Saitama-ken 359-0041</city><ctry>JP</ctry></adr></B721><B721><snm>KOSHI, Tomoyuki</snm><adr><str>2-4-4-206, Tate,
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