(19)

(11)

EP 1 663 118 A2

(12)

(88) Date of publication A3: 09.06.2005 (43) Date of publication: 07.06.2006 Bulletin 2006/23 (21) Application number: 04788667.6 (22) Date of filing: 08.09.2004

(51) International Patent Classification (IPC):  A61K 8/00(0000.00) (86) International application number: PCT/US2004/029514 (87) International publication number: WO 2005/025505 (24.03.2005 Gazette 2005/12)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 08.09.2003 US 501498 P 15.04.2004 US 562645 P (71) Applicant: E. I. du Pont de Nemours and Company Wilmington, Delaware 19898 (US)	(72) Inventors: HUANG, Xueying Hockessin, Delaware 19707 (US) WANG, Hong Kennett Square, Pennsylvania 19348 (US) WU, Ying Wallingford, Pennsylvania 19086 (US) (74) Representative: Matthews, Derek Peter et al Frank B. Dehn & Co. St Bride's House 10 Salisbury Square London EC4Y 8JD London EC4Y 8JD (GB)