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EP 1 663 234 A1

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(43) Date of publication: 07.06.2006 Bulletin 2006/23 (21) Application number: 04744202.5 (22) Date of filing: 04.08.2004

(51) International Patent Classification (IPC):  A61K 31/496(2000.01) A61K 31/495(1985.01) C07D 215/20(1985.01) C07D 401/12(1990.01) C07D 263/56(1985.01) C07D 213/64(1985.01) C07D 235/08(1985.01) C07D 249/08(1985.01) C07D 295/192(1990.01) A61K 31/18(1985.01) C07D 217/02(1985.01) C07D 231/56(1985.01) C07D 231/12(1985.01) C07D 215/26(1985.01) C07D 239/74(1985.01) (86) International application number: PCT/IB2004/002562 (87) International publication number: WO 2005/016344 (24.02.2005 Gazette 2005/08)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 14.08.2003 GB 0319149 22.09.2003 GB 0322153 24.03.2004 GB 0406656 (71) Applicants: Pfizer Limited Sandwich, Kent CT13 9NJ (GB) GB  PFIZER INC. New York, N.Y. 10017 (US) AT BE BG CH CY CZ DE DK EE ES FI FR GR HU IE IT LU MC NL PL PT RO SE SI SK TR

(72) Inventors: MIDDLETON, Donald Stuart, Pfizer Global R & D Sandwich, Kent CT13 9NJ (GB) MOWBRAY, Charles Eric, Pfizer Global R & D Sandwich, Kent CT13 9NJ (GB) STEPHENSON, Peter Thomas, Pfizer Global R & D Sandwich, Kent CT13 9NJ (GB) WILLIAMS, David Howard, Pfizer Global R & D Sandwich, Kent CT13 9NJ (GB) (74) Representative: Swarbrick, Terry Mark et al Pfizer Limited European Pharmaceutical Patent Department Ramsgate Road Sandwich, Kent CT13 9NJ Sandwich, Kent CT13 9NJ (GB)