(19)

(11)

EP 1 664 101 A2

(12)

(88) Date of publication A3: 02.06.2005 (43) Date of publication: 07.06.2006 Bulletin 2006/23 (21) Application number: 04765230.0 (22) Date of filing: 13.09.2004

(51) International Patent Classification (IPC):  C07K 14/31(1995.01) (86) International application number: PCT/EP2004/010317 (87) International publication number: WO 2005/023852 (17.03.2005 Gazette 2005/11)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 11.09.2003 WO PCT/EP03/10188 (71) Applicant: UMC Utrecht Holding B.V. 3584 CM Utrecht (NL)	(72) Inventors: VERHOEF, Jan NL-3707 EM Zeist (NL) MILATOVIC, Danica NL-2725 KW Zoetermeer (NL) EKKELENKAMP, Miquel, Bart NL-3522 PR Utrecht (NL) (74) Representative: van Kooij, Adriaan et al Arnold & Siedsma Sweelickplein 1 2517 GK The Hague 2517 GK The Hague (NL)