(19)

(11)

EP 1 664 112 A2

(12)

(88) Date of publication A3: 25.08.2005 (43) Date of publication: 07.06.2006 Bulletin 2006/23 (21) Application number: 04766696.1 (22) Date of filing: 03.09.2004

(51) International Patent Classification (IPC):  C07K 14/705(1995.01) C12N 5/10(1990.01) C07D 513/00(1985.01) G01N 33/94(1980.01) C07D 471/00(1985.01) (86) International application number: PCT/EP2004/052029 (87) International publication number: WO 2005/026208 (24.03.2005 Gazette 2005/12)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 12.09.2003 WO PCT/EP03/10263 (71) Applicant: JANSSEN PHARMACEUTICA N.V. 2340 Beerse (BE)	(72) Inventors: SMANS, Karine A. A., Janssen Pharmaceutica N.V. B-2340 Beerse (BE) GIJSEN, Henricus J. M., Janssen Pharmaceutica N.V. B-2340 Beerse (BE)