(19)

(11)

EP 1 664 124 A2

(12)

(88) Date of publication A3: 13.10.2005 (43) Date of publication: 07.06.2006 Bulletin 2006/23 (21) Application number: 04769152.2 (22) Date of filing: 12.08.2004

(51) International Patent Classification (IPC):  C07K 19/00(1995.01) A61P 33/06(2000.01) A61K 39/395(1985.01) C07K 16/20(1995.01) C12N 15/70(1990.01) C12N 1/21(1990.01) A61K 48/00(1990.01) A61K 39/385(1985.01) A61P 31/16(2000.01) A61K 39/42(1985.01) C07K 16/10(1995.01) C12N 15/79(1990.01) C12N 5/10(1990.01) (86) International application number: PCT/IB2004/002717 (87) International publication number: WO 2005/014654 (17.02.2005 Gazette 2005/07)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 12.08.2003 WO PCT/EP03/08926 (71) Applicant: Avidis SA 63360 Saint Beauzire (FR)	(72) Inventor: HILL, Fergal F-63360 Saint-Beauzire (FR) (74) Representative: Brasnett, Adrian Hugh et al Mewburn Ellis LLP York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)