(19)

(11)

EP 1 667 657 A1

(12)

(43) Date of publication: 14.06.2006 Bulletin 2006/24 (21) Application number: 04794159.6 (22) Date of filing: 04.10.2004

(51) International Patent Classification (IPC):  A61K 9/12(1974.07) A61P 29/00(2000.01) A61P 23/00(2000.01) A61K 31/00(1985.01) A61P 17/00(2000.01) A61P 31/00(2000.01) (86) International application number: PCT/US2004/032714 (87) International publication number: WO 2005/032522 (14.04.2005 Gazette 2005/15)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 03.10.2003 US 508495 P 09.04.2004 US 560890 P (71) Applicant: Collegium Pharmaceutical, Inc. Cumberland, RI 02864 (US)	(72) Inventors: HIRSH, Jane Wellesley, MA 02581 (US) WILLIS, John, C., II Mansfield, MA 02048 (US) HIRSH, Mark Wellesley, MA 02581 (US) (74) Representative: Bassett, Richard Simon  Eric Potter Clarkson LLP Park View House 58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)