(19)

(11)

EP 1 667 729 A2

(12)

(88) Date of publication A3: 26.05.2005 (43) Date of publication: 14.06.2006 Bulletin 2006/24 (21) Application number: 04776088.9 (22) Date of filing: 20.05.2004

(51) International Patent Classification (IPC):  A61K 48/00(1990.01) (86) International application number: PCT/US2004/016246 (87) International publication number: WO 2005/018537 (03.03.2005 Gazette 2005/09)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 23.05.2003 US 472888 P (71) Applicant: BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM Austin, TX 78701 (US)

(72) Inventors: GORENSTEIN, David G. Houston, TX 77059 (US) LUXON, Bruce A. Galveston, TX 77551 (US) HERZOG, Norbert Friendswood, TX 77546 (US) ARONSON, Judith F. Galveston, TX 77554 (US) BEASLEY, David Galveston, TX 77550 (US) BARRET, Allan Galveston, TX 77554 (US) SHOPE, Robert E. deceased (US) YANG, Xian Bin Webster, TX 77598 (US) (74) Representative: Sonn & Partner Patentanwälte  Riemergasse 14 1010 Wien 1010 Wien (AT)