(19)

(11)

EP 1 668 130 A2

(12)

(88) Date of publication A3: 30.06.2005 (43) Date of publication: 14.06.2006 Bulletin 2006/24 (21) Application number: 04784326.3 (22) Date of filing: 17.09.2004

(51) International Patent Classification (IPC):  C12N 15/11(1990.01) A61K 31/713(2000.01) A61P 9/00(2000.01) A61K 31/7088(2000.01) A61P 35/00(2000.01) (86) International application number: PCT/US2004/030436 (87) International publication number: WO 2005/028628 (31.03.2005 Gazette 2005/13)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 18.09.2003 US 504110 P 03.06.2004 US 576534 P (71) Applicants: ISIS PHARMACEUTICALS, INC. Carlsbad, CA 92008 (US) ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)

(72) Inventors: FREIER, Susan, M. San Diego, CA 92122 (US) DOBIE, Kenneth, W. Del Mar, CA 92014 (US) MARCUSSON, Eric, G. San Diego, CA 92111 (US) SWAYZE, Eric, E. Carlsbad, CA 92009 (US) BHAT, Balkrishen Carlsbad, CA 92009 (US) GRAFF, Jeremy, R. Indianapolis, IN 46228 (US) KONICEK, Bruce, W. Indianapolis, IN 46228 (US) (74) Representative: Burnside, Ivan John  Eli Lilly and Company Limited Lilly Research Centre Erl Wood Manor Sunninghill Road Windlesham, Surrey GU20 6PH Windlesham, Surrey GU20 6PH (GB)