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EP 1 670 516 A2

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(88) Date of publication A3: 14.07.2005 (43) Date of publication: 21.06.2006 Bulletin 2006/25 (21) Application number: 04770581.9 (22) Date of filing: 29.09.2004

(51) International Patent Classification (IPC):  A61K 47/48(1990.01) A01N 25/04(1985.01) A61P 25/28(2000.01) A61P 5/32(2000.01) A01N 43/653(1985.01) A61P 31/04(2000.01) A61P 31/10(2000.01) A61P 35/00(2000.01) (86) International application number: PCT/IL2004/000910 (87) International publication number: WO 2005/030257 (07.04.2005 Gazette 2005/14)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 30.09.2003 US 507623 P (71) Applicant: Solubest Ltd. 76702 Rehorot (IL)

(72) Inventors: GOLDSHTEIN, Rina 90411 Har Hebron (IL) KAMBURG, Roman 75315 Rishon Lezion (IL) RATNER, Galina 76519 Rehovot (IL) KOPYLOV, Michael 84253 Beer Sheva (IL) ZELKIND, Ilya 87540 Ofakim (IL) GOLDSHTEIN, Vadim 90411 Har Hebron (IL) SKYLARSKY, Olga 76551 Rehovot (IL) TULBOVICH, Boris 75781 Ashkelon (IL) STERN, Erwin 43610 Raanana (IL) (74) Representative: Vossius & Partner  Siebertstrasse 4 81675 München 81675 München (DE)