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(11)

EP 1 670 749 A1

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(43) Date of publication: 21.06.2006 Bulletin 2006/25 (21) Application number: 04768088.9 (22) Date of filing: 13.08.2004

(51) International Patent Classification (IPC):  C07C 235/38(1990.01) C07D 213/65(1985.01) C07D 271/06(1985.01) A61K 31/4412(2000.01) C07D 307/52(1985.01) C07D 231/12(1985.01) C07D 333/24(1985.01) A61P 9/10(2000.01) (86) International application number: PCT/GB2004/003528 (87) International publication number: WO 2005/016870 (24.02.2005 Gazette 2005/08)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: HR LT LV (30) Priority: 14.08.2003 GB 0319124 (71) Applicant: SMITHKLINE BEECHAM CORPORATION Philadelphia, Pennsylvania 19101 (US)

(72) Inventors: Campbell, Mathew, c/o GlaxoSmithKline Stevenage, Hertfordshire SG1 2NY (GB) Hatley, Richard Jonathan, c/o GlaxoSmithKline Stevenage, Hertfordshire SG1 2NY (GB) Heer, Jag Paul, c/o GlaxoSmithKline Harlow Essex CM19 5AW (GB) Mason, Andrew McMurtrie, c/o GlaxoSmithKline Stevenage, Hertfordshire SG1 2NY (GB) Nicholson, Neville Hubert, c/o GlaxoSmithKline Harlow, Essex CM19 5AW (GB) Pinto, Ivan Leo, c/o GlaxoSmithKline Stevenage, Hertfordshire SG1 2NY (GB) Rahman, Shahzad Sharooq, c/o GlaxoSmithKline Harlow, Essex CM19 5AW (GB) Smith, Ian Edward David, c/o GlaxoSmithKline Stevenage, Hertfordshire SG1 2NY (GB) (74) Representative: Thornley, Rachel Mary et al GlaxoSmithKline Corporate Intellectual Property (CN9.25.1) 980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)