RNA INTERFERENCE MEDIATED INHIBITION OF RAS GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

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EP 1 675 953 A2

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(88)	Date of publication A3:
	02.03.2006

(43)	Date of publication:
	05.07.2006 Bulletin 2006/27

(21)	Application number: 04816819.9

(22)	Date of filing: 20.08.2004

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International Patent Classification (IPC):

C12N 15/11^(1990.01)

(86)	International application number:
	PCT/US2004/027333

(87)	International publication number:
	WO 2005/040379 (06.05.2005 Gazette 2005/18)

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
	Designated Extension States:
	AL HR LT LV MK

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Priority:

23.10.2003 US 693059
24.11.2003 US 720448
03.12.2003 US 727780
14.01.2004 US 757803
10.02.2004 US 543480 P
13.02.2004 US 780447
16.04.2004 US 826966
30.04.2004 WO PCT/US20/04013456
24.05.2004 WO PCT/US20/04016390

(71)	Applicant: Sirna Therapeutics, Inc.
	Boulder, CO 80301 (US)

(72)	Inventor:
	MCSWIGGEN, James Boulder, CO 80301 (US)

(74)	Representative: Maschio, Antonio
	D Young & Co 120 Holborn London EC1N 2DY London EC1N 2DY (GB)

(54)	RNA INTERFERENCE MEDIATED INHIBITION OF RAS GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)