(19)

(11)

EP 1 677 763 A1

(12)

(43) Date of publication: 12.07.2006 Bulletin 2006/28 (21) Application number: 04780277.2 (22) Date of filing: 06.08.2004

(51) International Patent Classification (IPC):  A61K 9/127(1990.01) (86) International application number: PCT/US2004/025412 (87) International publication number: WO 2005/039534 (06.05.2005 Gazette 2005/18)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 01.10.2003 US 508035 P 13.02.2004 WO PCT/US20/04004295 (71) Applicant: Children's Hospital & Research Center at Oakland Oakland, CA 94609 (US)	(72) Inventors: RYAN, Robert, O. El Cerrito, CA 94530 (US) ODA, Michael, N. Fairfield, CA 94534 (US) (74) Representative: Roques, Sarah Elizabeth  J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)