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(11)

EP 1 677 788 A1

(12)

(43) Date of publication: 12.07.2006 Bulletin 2006/28 (21) Application number: 04795637.0 (22) Date of filing: 20.10.2004

(51) International Patent Classification (IPC):  A61K 31/44(1985.01) C07D 213/61(1985.01) C07D 213/30(1985.01) A61P 1/04(2000.01) (86) International application number: PCT/US2004/034501 (87) International publication number: WO 2005/044265 (19.05.2005 Gazette 2005/20)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 31.10.2003 US 560754 P (71) Applicants: AstraZeneca AB 151 85 Södertälje (SE) NPS PHARMACEUTICALS, INC. Salt Lake City, UT 84108 (US)	(72) Inventors: BACH, Peter, AstraZeneca R & D Molndal S-431 Molndal (SE) BAUER, Udo, AstraZeneca R & D Molndal S-431 Molndal (SE) NILSSON, Karolina, AstraZeneca R & D Molndal S-431 Molndal (SE) WALLBERG, Andreas, AstraZeneca R & D Molndal S-431 Molndal (SE) (74) Representative: Plougmann & Vingtoft A/S  Sundkrogsgade 9, P.O. Box 831 2100 Copenhagen Ø 2100 Copenhagen Ø (DK)