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EP 1 678 146 A1

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(43) Date of publication: 12.07.2006 Bulletin 2006/28 (21) Application number: 04769607.5 (22) Date of filing: 11.10.2004

(51) International Patent Classification (IPC):  C07D 239/42(1985.01) A61K 31/505(1985.01) C07D 401/04(1990.01) A61K 31/506(2000.01) (86) International application number: PCT/IB2004/003314 (87) International publication number: WO 2005/040133 (06.05.2005 Gazette 2005/18)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 23.10.2003 US 513770 P (71) Applicant: Pharmacia Corporation Chesterfield, MO 63017-1732 (US)

(72) Inventors: CLARE, Michael, Pfizer Global Res. and Dev. Chesterfield, MO63017-1732 (US) HAGEN, Timothy J., Pfizer Global Res. and Dev. Ann Arbor, MI 48105 (US) HOUDEK, Stephen C., Pfizer Global Res. and Dev. Chesterfield, MO 63017-1732 (US) LENNON, Patrick J., Pfizer Global Res. and Dev. Chesterfield, MO 63017-1732 (US) WEIER, Richard M., Pfizer Global Res. and Dev. Chesterfield, MO 63017-1732 (US) XU, Xiangdong, Pfizer Global Res. and Dev. Chesterfield, MO 63017-1732 (US) (74) Representative: Nevant, Marc  Pfizer European Pharma Patent Department 23-25, avenue du Docteur Lannelongue 75668 Paris Cedex 14 75668 Paris Cedex 14 (FR)