(19)
(11) EP 1 680 499 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.03.2012 Bulletin 2012/12

(45) Mention of the grant of the patent:
14.12.2011 Bulletin 2011/50

(21) Application number: 04791033.6

(22) Date of filing: 29.10.2004
(51) International Patent Classification (IPC): 
C12N 1/00(2006.01)
(86) International application number:
PCT/EP2004/012273
(87) International publication number:
WO 2005/049786 (02.06.2005 Gazette 2005/22)

(54)

MODULATION OF ANGIOGENESIS BY BARTONELLA HENSELAE

MODULATION DER ANGIOGENESE DURCH BARTONELLA HENSELAE

MODULATION DE L'ANGIOGENESE PAR LA BARTONELLA HENSELAE

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

(30) Priority: 05.11.2003 DE 10351627

(43) Date of publication of application:
19.07.2006 Bulletin 2006/29

(73) Proprietor: Eberhard-Karls-Universität Tübingen Universitätsklinikum
72076 Tübingen (DE)

(72) Inventors:
  • KEMPF, Volkhard
    72072 Tübingen (DE)
  • RIESS, Tanja
    72076 Tübingen (DE)
  • AUTENRIETH, Ingo
    72070 Tübingen (DE)
  • ALITALO, Kari
    00260 Helsinki (FI)
  • ANDERSON, Siv, Dept. of Molecular Evolution
    752 36 Uppsala (SE)

(74) Representative: Findeisen, Marco et al
Witte, Weller & Partner Patentanwälte Postfach 10 54 62
70047 Stuttgart
70047 Stuttgart (DE)


(56) References cited: : 
US-B1- 6 406 887
   
  • KEMPF V A ET AL: "Evidence of a leading role for VEGF in Bartonella henselae-induced endothelial cell proliferations." CELLULAR MICROBIOLOGY. SEP 2001, vol. 3, no. 9, September 2001 (2001-09), pages 623-632, XP002319135 ISSN: 1462-5814 cited in the application
  • BURGESS ANDREW W ET AL: "Outer membrane proteins of Bartonella henselae and their interaction with human endothelial cells" MICROBIAL PATHOGENESIS, vol. 25, no. 3, September 1998 (1998-09), pages 157-164, XP002319136 ISSN: 0882-4010
  • REGNERY R L ET AL: "CHARACTERIZATION OF A NOVEL ROCHALIMAEA-SPP ROCHALIMAEA-HENSELAE NEW-SPECIES ISOLATED FROM BLOOD OF A FEBRILE HUMAN IMMUNODEFICIENCY VIRUS-POSITIVE PATIENT" JOURNAL OF CLINICAL MICROBIOLOGY, vol. 30, no. 2, 1992, pages 265-274, XP000904509 ISSN: 0095-1137
  • RIESS TANJA ET AL: "Rapid and efficient transposon mutagenesis of Bartonella henselae by transposome technology." GENE. 14 AUG 2003, vol. 313, 14 August 2003 (2003-08-14), pages 103-109, XP002319137 ISSN: 0378-1119
  • RIESS TANJA ET AL: "Bartonella adhesin a mediates a proangiogenic host cell response." THE JOURNAL OF EXPERIMENTAL MEDICINE. 15 NOV 2004, vol. 200, no. 10, 15 November 2004 (2004-11-15), pages 1267-1278, XP002319138 ISSN: 0022-1007
  • ALSMARK CECILIA M ET AL: "The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 29 JUN 2004, vol. 101, no. 26, 29 June 2004 (2004-06-29), pages 9716-9721, XP002319350 ISSN: 0027-8424
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).