(19)

(11)

EP 1 684 777 A2

(12)

(88) Date of publication A3: 03.11.2005 (43) Date of publication: 02.08.2006 Bulletin 2006/31 (21) Application number: 04821554.5 (22) Date of filing: 13.08.2004

(51) International Patent Classification (IPC):  A61K 36/064(2006.01) A61P 9/10(2006.01) A61K 31/716(2006.01) A61P 7/06(2006.01) (86) International application number: PCT/US2004/026359 (87) International publication number: WO 2005/084692 (15.09.2005 Gazette 2005/37)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 13.08.2003 US 494772 P (71) Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. Louisville, KY 40292 (US)	(72) Inventors: ROSS, Gordon, D. deceased (US) RATAJCZAK, Mariusz, Z. Louisville, KY 40245 (US) (74) Representative: Roques, Sarah Elizabeth  J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)