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EP 1 685 124 A1

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(43) Date of publication: 02.08.2006 Bulletin 2006/31 (21) Application number: 04798442.2 (22) Date of filing: 09.11.2004

(51) International Patent Classification (IPC):  C07D 401/04(2006.01) C07D 471/04(2006.01) A61K 31/4725(2006.01) C07D 401/14(2006.01) C07D 403/04(2006.01) A61P 43/00(2006.01) (86) International application number: PCT/GB2004/004719 (87) International publication number: WO 2005/047279 (26.05.2005 Gazette 2005/21)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: LT LV (30) Priority: 10.11.2003 GB 0326217 05.04.2004 GB 0407748 08.10.2004 US 617134 P (71) Applicant: MERCK SHARP & DOHME LTD. Hoddesdon, Hertfordshire EN11 9BU (GB)

(72) Inventors: HOLLINGWORTH, Gregory, John Terlings Park Harlow Essex CM20 2QR (GB) JONES, Brian, A. Harlow Essex CM20 2QR (GB) MCIVER, Edward, Giles Harlow Essex CM20 2QR (GB) MOYES, Christopher, Richard Harlow Essex CM20 2QR (GB) ROGERS, Lauren Harlow Essex CM20 2QR (GB) (74) Representative: Buchan, Gavin MacNicol et al Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)