(19)

(11)

EP 1 685 160 A1

(12)

(43) Date of publication: 02.08.2006 Bulletin 2006/31 (21) Application number: 04798463.8 (22) Date of filing: 10.11.2004

(51) International Patent Classification (IPC):  C07K 14/81(2006.01) A61K 9/16(2006.01) A61K 38/57(2006.01) A61K 9/19(2006.01) (86) International application number: PCT/GB2004/004740 (87) International publication number: WO 2005/047323 (26.05.2005 Gazette 2005/21)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 10.11.2003 US 518803 P 14.11.2003 US 519946 P (71) Applicant: Arriva-Prometic Inc. Montreal, Quebec H4P 2R2 (CA)	(72) Inventors: NAYAR, Rajiv Alameda, CA 94501 (US) MANNING, Mark, G. Alameda, CA 94501 (US) BARR, Philip, J. Alameda, CA 94501 (US) PEMBERTON, Philip, A. Alameda, CA 94501 (US) BATHURST, Ian, C. Alameda, CA 94501 (US) GIBSON, Helen Alameda, CA 94501 (US) (74) Representative: Perry, Robert Edward  Gill Jennings & Every LLP Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)