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(11)

EP 1 686 994 A2

(12)

(88) Date of publication A3: 21.07.2005 (43) Date of publication: 09.08.2006 Bulletin 2006/32 (21) Application number: 04797932.3 (22) Date of filing: 16.11.2004

(51) International Patent Classification (IPC):  A61K 31/4439(2006.01) A61K 31/426(2006.01) A61K 31/40(2006.01) A61K 31/472(2006.01) A61P 9/10(2006.01) A61K 31/4025(2006.01) A61K 31/4985(2006.01) A61K 31/403(2006.01) A61P 9/04(2006.01) A61P 13/12(2006.01) (86) International application number: PCT/EP2004/012990 (87) International publication number: WO 2005/049022 (02.06.2005 Gazette 2005/22)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 17.11.2003 US 520562 P 17.11.2003 US 520563 P 24.02.2004 US 547191 P 24.02.2004 US 547192 P (71) Applicants: Novartis AG 4056 Basel (CH) BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LU MC NL PL PT RO SE SI SK TR  NOVARTIS-PHARMA GMBH 1230 Vienna (AT) AT

(72) Inventors: PRATLEY, Richard Sparta, NJ 07871 (US) FOLEY, James, E. Sparta, NJ 07871 (US) HUGHES, Thomas, Edward Concord, MA 01742 (US) (74) Representative: Crawley, Patrick Edward  Novartis AG Corporate Intellectual Property 4002 Basel 4002 Basel (CH)