(19)

(11)

EP 1 686 998 A1

(12)

(43) Date of publication: 09.08.2006 Bulletin 2006/32 (21) Application number: 04769658.8 (22) Date of filing: 18.10.2004

(51) International Patent Classification (IPC):  A61K 31/505(2006.01) A01K 67/027(2006.01) C12N 15/11(2006.01) A61K 38/46(2006.01) C12N 5/06(2006.01) (86) International application number: PCT/IB2004/003396 (87) International publication number: WO 2005/041972 (12.05.2005 Gazette 2005/19)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 31.10.2003 US 516213 P (71) Applicant: Pfizer Products Inc. Groton, Connecticut 06340 (US)	(72) Inventors: BLACK, Shawn, Clive Groton, CT 06340 (US) GIBBS, Earl, Michael Groton, CT 06340 (US) MCNEISH, John, Douglas Groton, CT 06340 (US) (74) Representative: Vanhee-Brossollet, Christine  Pfizer European Pharma Patent Department 23-25, avenue du Docteur Lannelongue 75668 Paris Cedex 14 75668 Paris Cedex 14 (FR)