(19)

(11)

EP 1 687 029 A1

(12)

(43) Date of publication: 09.08.2006 Bulletin 2006/32 (21) Application number: 03816309.3 (22) Date of filing: 14.11.2003

(51) International Patent Classification (IPC):  A61K 39/40(2006.01) C07K 16/00(2006.01) A61K 39/395(2006.01) C12P 21/08(2006.01) (86) International application number: PCT/US2003/036555 (87) International publication number: WO 2005/056052 (23.06.2005 Gazette 2005/25)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR (71) Applicant: AVANIR PHARMACEUTICALS San Diego, California 92121 (US)	(72) Inventors: MORROW, Phillip, R. deceased (US) KANG, Angray, S. Encinitas, CA 92024 (US) WANG, Fei San Diego, CA 92129 (US) JIANG, Ivy San Diego, CA 9213 (US) SAWADA-HIRAI, Ritsuko San Diego, CA 92130 (US) SCHOLZ, Wolfgang San Diego, CA 92129 (US) (74) Representative: Smaggasgale, Gillian Helen  W.P. Thompson & Co, 55 Drury Lane London WC2B 5SQ London WC2B 5SQ (GB)