(19)
(11) EP 1 687 413 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
01.10.2008 Bulletin 2008/40

(45) Mention of the grant of the patent:
05.03.2008 Bulletin 2008/10

(21) Application number: 03754305.5

(22) Date of filing: 29.10.2003
(51) International Patent Classification (IPC): 
C12N 5/02(2006.01)
 C12N 5/08(2006.01)
(86) International application number:
PCT/KR2003/002302
(87) International publication number:
WO 2005/040362 (06.05.2005 Gazette 2005/18)

(54)

METHOD FOR DIFFERENTIATING MESENCHYMAL STEM CELL INTO NEURAL CELL AND PHARMACEUTICAL COMPOSITION CONTAINING THE NEURAL CELL FOR NEURODEGENERATIVE DISEASE

VERFAHREN ZUR DIFFERENZIERUNG EINER MESENCHYM-STAMMZELLE ZU EINER NERVENZELLE SOWIE DIE NERVENZELLE ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNG GEGEN EINE NEURODEGENERATIVE KRANKHEIT

PROCEDE PERMETTANT DE DIFFERENTIER UNE CELLULE SOUCHE MESENCHYMATEUSE DANS UNE CELLULE NERVEUSE ET COMPOSITION PHARMACEUTIQUE CONTENANT LA CELLULE NERVEUSE POUR LES MALADIES NEURODEGENERESCENTES

(84) Designated Contracting States:
AT DE FR GB IT NL

(43) Date of publication of application:
09.08.2006 Bulletin 2006/32

(73) Proprietors:
  • FCB Pharmicell Co., Ltd
    Kyunggi-do 462-120 (KR)
  • Kim, Hyun-Soo
    Suwon-si, Kyunggi-do 443-737 (KR)

(72) Inventors:
  • KIM, Hyun-Soo
    Youngtong-dong, Youngtong-gu, Suwon-si, Kyunggi-do 443-737 (KR)
  • KANG, Young-Mo
    Suwon-si, 441-829 Kyunggi-do (KR)
  • LEE, Kyung-Bock
    Suwon-si, 442-373 Kyunggi-do (KR)
  • PARK, Sang-Kyo
    Paldal-gu, Suwon-si, 442-733 Kyunggi-do (KR)
  • LEE, Sang-Kap
    706-766 Daegu-si (KR)

(74) Representative: Hiebl, Inge Elisabeth 
Kraus & Weisert Patent- und Rechtsanwälte Thomas-Wimmer-Ring 15
80539 München
80539 München (DE)


(56) References cited: : 
WO-A1-96/15226
US-A- 5 942 225
 WO-A1-02/086108
US-B1- 6 214 334
   
  • TAO HELEN ET AL: "Transdifferentiation of Human Haemopoietic Lineage Negative Bone Marrow Cells to Neural Cells by Cytokines and Chemical Inducing Agents." BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), page Abstract No. 4123, XP009073026 & 44TH ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY; PHILADELPHIA, PA, USA; DECEMBER 06-10, 2002 ISSN: 0006-4971
  • OH Y S ET AL: "DIFFERENTIATION OF ADULT BONE MARROW STEM CELLS INTO NEURON-LIKE CELLS" ABSTRACTS OF THE SOCIETY FOR NEUROSCIENCE, SOCIETY FOR NEUROSCIENCE, WASHINGTON, DC, US, vol. 27, no. 1, 2001, page 58, XP009054180 ISSN: 0190-5295
  • KOICHI I ET AL: "HUMAN PLACENTA-DERIVED MESENCHYMAL STEM CELLS DIFFERENTIATE INTO NEURAL CELLS" BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 100, no. 11, 16 November 2002 (2002-11-16), page ABSTRNO2021, XP008061487 ISSN: 0006-4971
  • REYES M ET AL: "TURNING MARROW INTO BRAIN: GENERATION OF GLIAL AND NEURONAL CELLS FROM ADULT BONE MARROW MESENCHYMAL STEM CELLS" BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 94, no. 10,SUPP01PART01, 15 November 1999 (1999-11-15), page 377A, XP009007196 ISSN: 0006-4971
  • SANCHEZ-RAMOS J. ET AL.: 'Adult bone marrow stromal cells differentiate into neural cells in vitro' EXP. NEUROL. vol. 164, no. 2, August 2000, pages 247 - 256, XP002199139
  • SCHULDINER M. ET AL.: 'Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells' PROC. NATL. ACAD. SCI. USA vol. 97, no. 21, 10 October 2000, pages 11307 - 11312, XP002184277
  • SUGAYA K. ET AL.: 'Neuroplacement therapy and stem cell biology under disease conditions' CELL. MOL. LIFE SCI. vol. 60, no. 9, September 2003, pages 1891 - 1902, XP008071706
   
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