(19)

(11)

EP 1 687 451 A2

(12)

(88) Date of publication A3: 09.06.2005 (43) Date of publication: 09.08.2006 Bulletin 2006/32 (21) Application number: 04817129.2 (22) Date of filing: 29.09.2004

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) (86) International application number: PCT/US2004/032446 (87) International publication number: WO 2005/033340 (14.04.2005 Gazette 2005/15)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 30.09.2003 US 507787 P (71) Applicant: Applera Corporation Bedford, MA 01730-2203 (US)	(72) Inventors: WILLIAMS, Brett Lexington, Massachusetts 02421 (US) JOHANSEN, Jack Concord, Massachusetts 01742 (US) HYLDIG-NIELSEN, Jens, J. Holliston, Massachusetts 01746 (US) (74) Representative: Gallagher, Kirk James  D Young & Co 120 Holborn London EC1N 2DY London EC1N 2DY (GB)