(19)

(11)

EP 1 689 230 A2

(12)

(88) Date of publication A3: 03.11.2005 (43) Date of publication: 16.08.2006 Bulletin 2006/33 (21) Application number: 04810994.6 (22) Date of filing: 15.11.2004

(51) International Patent Classification (IPC):  A01N 43/04(2006.01) A61K 31/70(2006.01) (86) International application number: PCT/US2004/038060 (87) International publication number: WO 2005/049850 (02.06.2005 Gazette 2005/22)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK YU (30) Priority: 14.11.2003 US 520460 P (71) Applicant: University of Washington Seattle, WA 98105-4608 (US)	(72) Inventors: CHAMBERLAIN, Jeffrey, S. Seattle, WA 98105 (US) GREGOREVIC, Paul Seattle, WA 98115 (US) BLANKINSHIP, Michael, J. Seatle, WA 98107 (US) ALLEN, James, M. Seattle, WA 98115 (US) (74) Representative: Glawe, Delfs, Moll  Patent- und Rechtsanwälte, Rothenbaumchaussee 58 20148 Hamburg 20148 Hamburg (DE)