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(11)

EP 1 689 439 A2

(12)

(88) Date of publication A3: 22.09.2005 (43) Date of publication: 16.08.2006 Bulletin 2006/33 (21) Application number: 04784836.1 (22) Date of filing: 22.09.2004

(51) International Patent Classification (IPC):  A61K 47/48(2006.01) A61K 31/337(2006.01) A61K 31/475(2006.01) C07H 21/00(2006.01) A61K 31/704(2006.01) (86) International application number: PCT/US2004/031147 (87) International publication number: WO 2005/030258 (07.04.2005 Gazette 2005/14)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 22.09.2003 US 505325 P 22.06.2004 US 581835 P (71) Applicant: Acidophil LLC San Diego, CA 92121 (US)

(72) Inventors: CASTELLINO, Angelo, John San Diego, CA 92117 (US) ASPLAND, Simon, Eric La Jolla, CA 92037 (US) BALLATORE, Carlo San Diego, CA 92130 (US) DESHARNAIS, Joel San Diego, CA 32110 (US) NEWMAN, Michael, James San Diego, CA 92130 (US) SUN, Chengzao San Diego, CA 92117 (US) WIRSCHING, Peter La Jolla, CA 92037 (US) (74) Representative: Jones Day  Rechtsanwälte, Attorneys-at-Law, Patentanwälte Prinzregentenstrasse 11 80538 München 80538 München (DE)