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EP 1 689 493 A1

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(43) Date of publication: 16.08.2006 Bulletin 2006/33 (21) Application number: 03819270.4 (22) Date of filing: 05.12.2003

(51) International Patent Classification (IPC):  A61P 25/06(2006.01) A61K 31/52(2006.01) A61K 31/54(2006.01) A61K 31/50(2006.01) C07D 243/10(2006.01) C07D 285/00(2006.01) A61K 31/535(2006.01) A61K 31/55(2006.01) A61K 31/495(2006.01) C07D 239/00(2006.01) C07D 265/00(2006.01) (86) International application number: PCT/US2003/038799 (87) International publication number: WO 2005/065779 (21.07.2005 Gazette 2005/29)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (71) Applicant: Bristol-Myers Squibb Pharma Company Princeton, New Jersey 08543-4000 (US)

(72) Inventors: DEGNAN, Andrew, P. New Haven, CT 06511 (US) CHEN, Ling Middletown, CT 06457 (US) CIVIELLO, Rita Killingworth, CT 06419 (US) DUBOWCHIK, Gene, M. Middlefield, CT 06455 (US) HAN, Xiaojun Cheshire, CT 06410 (US) JIANG, Xiang, Jun, J. Hamden, CT 06514 (US) MACOR, John, E. Guilford, CT 06437 (US) TORA, George Meriden, CT 06450 (US) LUO, Guanglin Madison, CT 06443 (US) (74) Representative: Reitstötter - Kinzebach  Patentanwälte Sternwartstrasse 4 81679 München 81679 München (DE)