(19)

(11)

EP 1 689 714 A2

(12)

(88) Date of publication A3: 15.09.2005 (43) Date of publication: 16.08.2006 Bulletin 2006/33 (21) Application number: 04801265.2 (22) Date of filing: 06.12.2004

(51) International Patent Classification (IPC):  C07D 213/20(2006.01) A61K 31/4425(2006.01) A61P 37/00(2006.01) A61P 9/06(2006.01) A61K 45/06(2006.01) C07D 495/04(2006.01) A61K 31/4439(2006.01) A61P 37/06(2006.01) A61P 3/10(2006.01) (86) International application number: PCT/GB2004/005109 (87) International publication number: WO 2005/054198 (16.06.2005 Gazette 2005/24)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 05.12.2003 GB 0328314 (71) Applicant: UNIVERSITY OF BATH Claverton Down, Bath, BA2 7AY (GB)	(72) Inventors: POTTER, B.V.l University of Bath Bath BA2 7AY (GB) DOWDEN, James, University of Bath Bath BA2 7AY (GB) GALIONE, Antony, Oxford University Oxford OX1 3QT (GB) (74) Representative: Harding, Charles Thomas et al D Young & Co 120 Holborn London EC1N 2DY London EC1N 2DY (GB)