(19)

(11)

EP 1 694 315 A2

(12)

(88) Date of publication A3: 20.10.2005 (43) Date of publication: 30.08.2006 Bulletin 2006/35 (21) Application number: 04813394.6 (22) Date of filing: 03.12.2004

(51) International Patent Classification (IPC):  A61K 31/00(2006.01) C07K 1/00(2006.01) (86) International application number: PCT/US2004/041070 (87) International publication number: WO 2005/055950 (23.06.2005 Gazette 2005/25)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 03.12.2003 US 527089 P 26.01.2004 US 539387 P 29.07.2004 US 592744 P 29.09.2004 US 614518 P 29.10.2004 US 623387 P (71) Applicant: Neose Technologies, Inc. Horsham, PA 19044 (US)	(72) Inventors: DEFREES, Shawn North Wales, PA 19454 (US) BAYER, Robert, J. San Diego, CA 92122 (US) BOWE, Caryn Doylestown, PA 18901 (US) PANNEERSELVAM, Krishnasamy Poway, CA 92064 (US) (74) Representative: Harrison Goddard Foote  Belgrave Hall Belgrave Street Leeds LS2 8DD Leeds LS2 8DD (GB)