(19)

(11)

EP 1 694 834 A1

(12)

(43) Date of publication: 30.08.2006 Bulletin 2006/35 (21) Application number: 04806080.0 (22) Date of filing: 15.12.2004

(51) International Patent Classification (IPC):  C12N 9/24(2006.01) C12P 19/04(2006.01) C12N 9/26(2006.01) (86) International application number: PCT/GB2004/005266 (87) International publication number: WO 2005/059126 (30.06.2005 Gazette 2005/26)

(84) Designated Contracting States: DE FR GB (30) Priority: 15.12.2003 GB 0329011 (71) Applicant: ISIS INNOVATION LIMITED Summertown, Oxford OX2 7SG (GB)	(72) Inventor: DAVIS, Benjamin, Guy, c/oUniverstiy of Oxford Oxford OX1 3TA (GB) (74) Representative: Campbell, Patrick John Henry  J.A. Kemp & Co., 14 South Square, Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)