(19)

(11)

EP 1 694 839 A2

(12)

(88) Date of publication A3: 03.11.2005 (43) Date of publication: 30.08.2006 Bulletin 2006/35 (21) Application number: 04803013.4 (22) Date of filing: 13.12.2004

(51) International Patent Classification (IPC):  C12N 15/11(2006.01) A61K 39/395(2006.01) A61P 37/00(2006.01) A61K 31/713(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/DK2004/000860 (87) International publication number: WO 2005/056598 (23.06.2005 Gazette 2005/25)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 12.12.2003 US 529067 P (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: MATHIASEN, Ida Stenfeldt DK-2800 Kgs Lyngby (DK) BAUER, Michael Karl DK-2720 Vanløse (DK) MÜLLER, Jörn Roland DK-2830 Virum (DK)