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(11)

EP 1 694 843 A1

(12)

(43) Date of publication: 30.08.2006 Bulletin 2006/35 (21) Application number: 04820427.5 (22) Date of filing: 09.12.2004

(51) International Patent Classification (IPC):  C12N 15/11(2006.01) G06F 17/50(2006.01) G06N 3/10(2006.01) (86) International application number: PCT/EP2004/014037 (87) International publication number: WO 2005/059132 (30.06.2005 Gazette 2005/26)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (30) Priority: 10.12.2003 US 528430 P (71) Applicants: Novartis AG 4056 Basel (CH) BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR  NOVARTIS-PHARMA GMBH 1230 Vienna (AT) AT	(72) Inventors: HALL, Jonathan CH-4143 Dornach (CH) HUESKEN, Dieter 79102 Freiburg i-Br. (DE) LANGE, Jörg, Bernd 79102 Freiburg i. Br. (DE) NATT, Francois, Jean-Charles CH-4147 Aesch (CH) REINHARDT, Mischa, Werner, Henri, Marie F-68490 Bantzenheim (FR) (74) Representative: Crawley, Patrick Edward et al Novartis AG Corporate Intellectual Property 4002 Basel 4002 Basel (CH)