(19)
(11) EP 1 697 522 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
01.09.2010 Bulletin 2010/35

(45) Mention of the grant of the patent:
14.07.2010 Bulletin 2010/28

(21) Application number: 04798638.5

(22) Date of filing: 22.11.2004
(51) International Patent Classification (IPC): 
C12N 15/68(2006.01)
A61K 35/74(2006.01)
C12N 15/64(2006.01)
(86) International application number:
PCT/GB2004/004929
(87) International publication number:
WO 2005/052167 (09.06.2005 Gazette 2005/23)

(54)

PLASMID MAINTENANCE

PLASMIDAUFRECHTERHALTUNG

MAINTIEN DE PLASMIDE


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LU MC NL PL PT RO SE SI SK TR
Designated Extension States:
AL HR LT LV MK YU

(30) Priority: 20.11.2003 GB 0327056

(43) Date of publication of application:
06.09.2006 Bulletin 2006/36

(73) Proprietor: RPH PHARMACEUTICALS AB
136 50 Haninga (SE)

(72) Inventor:
  • CRANENBURGH, Rocky Marc, Cobra Biologics Limited
    Keele ST5 5SP (GB)

(74) Representative: Hallybone, Huw George et al
Carpmaels & Ransford One Southampton Row
London WC1B 5HA
London WC1B 5HA (GB)


(56) References cited: : 
EP-A- 0 851 932
WO-A-02/079467
WO-A-97/14805
US-B1- 6 413 768
   
  • BRANTL SABINE: "Antisense RNAs in plasmids: Control of replication and maintenance." PLASMID, vol. 48, no. 3, November 2002 (2002-11), pages 165-173, XP002327899 ISSN: 0147-619X cited in the application
  • WEAVER KEITH E ET AL: "Functional analysis of the Enterococcus faecalis plasmid pAD1-encoded stability determinant par" MOLECULAR MICROBIOLOGY, vol. 20, no. 1, 1996, pages 53-63, XP008046813 ISSN: 0950-382X
  • WILLIAMS S G ET AL: "Repressor titration: A novel system for selection and stable maintenance of recombinant plasmids" NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 26, no. 9, 1 May 1998 (1998-05-01), pages 2120-2124, XP002253526 ISSN: 0305-1048 cited in the application
  • ZIELENKIEWICZ URSZULA ET AL: "Mechanisms of plasmid stable maintenance with special focus on plasmid addiction systems" ACTA BIOCHIMICA POLONICA, vol. 48, no. 4, 2001, pages 1003-1023, XP002327900 ISSN: 0001-527X
  • DELIHAS N: "REGULATION OF GENE EXPRESSION BY TRANS-ENCODED ANTISENSE RNAS" MOLECULAR MICROBIOLOGY, BLACKWELL SCIENTIFIC, OXFORD, GB, vol. 15, no. 3, 1995, pages 411-414, XP001029329 ISSN: 0950-382X
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).