| (19) |
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(11) |
EP 1 698 630 A8 |
| (12) |
CORRECTED EUROPEAN PATENT APPLICATION |
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Note: Bibliography reflects the latest situation |
| (15) |
Correction information: |
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Corrected version no 1 (W1 A1) |
| (48) |
Corrigendum issued on: |
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25.10.2006 Bulletin 2006/43 |
| (43) |
Date of publication: |
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06.09.2006 Bulletin 2006/36 |
| (22) |
Date of filing: 03.03.2005 |
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| (51) |
International Patent Classification (IPC):
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| (84) |
Designated Contracting States: |
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AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI
SK TR |
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Designated Extension States: |
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AL BA HR LV MK YU |
| (71) |
Applicant: ALFA WASSERMANN S.p.A. |
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65020 Alanno Scalo (Pescara) (IT) |
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| (72) |
Inventors: |
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- Viscomi, Giuseppe Claudio
40037 Sasso Marconi, Bologna (IT)
- Campana, Manuela
40134 Bologna, (IT)
- Confortini, Donatella
40012 Calderara di Reno, Bologna (IT)
- Barbanti, Maria Miriam
40136 Bologna (IT)
- Braga, Dario
40133 Bologna (IT)
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| (74) |
Representative: Hiebl, Inge Elisabeth et al |
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Kraus & Weisert
Patent- und Rechtsanwälte
Thomas-Wimmer-Ring 15
80539 München
80539 München (DE) |
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| (54) |
New polymorphous forms of rifaximin, processes for their production and use thereof
in the medicinal preparations |
(57) Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin
δ and rifaximin ε useful in the production of medicinal preparations containing rifaximin
for oral and topical use and obtained by means of a crystallization process carried
out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization
of the product by addition of water at a determinate temperature and for a determinate
period of time, followed by a drying carried out under controlled conditions until
reaching a settled water content in the end product, are the object of the invention.